Intraosseous (IO) access is a lifesaving alternative when peripheral IV access fails, especially in critically ill or arresting pediatric patients. It provides rapid vascular access by delivering fluids and medications directly into the bone marrow, which acts as a non-collapsible venous network.
Why is IO Access Important?
IO access is indicated when peripheral IV access is not quickly achievable, typically within 60-90 seconds in a critically ill child.
Common Indications:
Failure to obtain IV access after multiple attempts.
Cardiac arrest or life-threatening shock.
Severe dehydration requiring immediate fluid resuscitation.
Status epilepticus requiring urgent IV medication.
Sepsis, trauma, or burns where venous access is challenging.
Contraindications:
The best IO site depends on the child’s age, anatomy, and clinical condition.
Site Best For Landmarks
Proximal Tibia (Most Common) All ages 1-2 cm below tibial tuberosity, medial to tibial shaft
Distal Femur Infants & small children Midline, 1-2 cm above patella, perpendicular to femur
Proximal Humerus (Preferred in older children/adolescents) Larger children & adolescents Greater tubercle, lateral to bicipital groove
Proximal Tibia is the first-line site in most children due to ease of access and large marrow cavity.
Humeral Head is preferred in older children and adolescents as it allows faster systemic drug delivery due to proximity to the heart.
Avoid placing IO lines in fractured bones or sites with prior IO attempts (to prevent extravasation).
Position and Prepare the Site
Insert the IO Needle
Confirm Proper Placement
Aspiration of bone marrow (not always present).
Flush with 5-10 mL saline – should flow easily without resistance.
No signs of swelling or extravasation at the site.
Secure the IO Line
If the flush does not flow freely, suspect malposition or extravasation and remove the IO.
Common Complications:
Complication Cause Solution
Extravasation (Fluid Leakage) Misplaced IO or excessive movement Remove IO, apply pressure, and use another site
Infection (Osteomyelitis) Prolonged IO placement (>24 hours) Remove IO ASAP if signs of infection
Pain with Infusion No pain control in conscious patients Give lidocaine flush before fluids
Fracture Incorrect placement or excessive force Use an alternative site
If extravasation occurs, stop infusion immediately and monitor for compartment syndrome.
Any IV medication or fluid can be given via IO access. The absorption rate is similar to a central venous line.
Normal saline, lactated Ringer’s, D5W
Blood products (packed RBCs, plasma)
Glucose (D10, D25, D50) for hypoglycemia
Epinephrine (1:10,000) – 0.01 mg/kg IV/IO for cardiac arrest
Atropine, adenosine, amiodarone (PALS drugs)
Sodium bicarbonate (for metabolic acidosis)
Antibiotics (if sepsis is suspected)
Give all medications with a 5-10 mL saline flush to ensure delivery into circulation.
Feature Peripheral IV Intraosseous (IO)
Speed of Placement Slower, especially in critically ill children Faster (within 30-60 seconds)
Reliability Can be difficult in shock/dehydration Reliable, non-collapsible venous access
Usability First-line in most cases Used only when IV access fails
Medications & Fluids Any IV-compatible drugs Same as IV, including blood products
Complications Infiltration, phlebitis Extravasation, osteomyelitis, fracture
IO access should be attempted immediately if IV attempts fail in critically ill children.
IO access is the fastest and most reliable alternative when IV access is not available.
Proximal tibia is the preferred site in most children; humeral head is ideal for older children.
All emergency medications and fluids can be given IO.
IO should be removed within 24 hours to prevent complications.
Takeaway: In life-threatening pediatric emergencies, IO access can be the difference between life and death. Mastering this technique ensures rapid intervention when time is critical.